Catastrophic Antiphospholipid Syndrome: Candidate Therapies for a Potentially Lethal Disease. Review uri icon

Overview

abstract

  • Catastrophic antiphospholipid syndrome (CAPS) is a potentially lethal disease that presents with rapidly progressive multiple organ thromboses. Anticoagulation, corticosteroids, intravenous immunoglobulin, and plasma exchange are the most commonly used treatments for CAPS patients. However, the high mortality despite these medications necessitates new treatment strategies. Following a brief review of current diagnostic and management strategies, we discuss the candidate therapies, i.e., hydroxychloroquine, rituximab, eculizumab, sirolimus, and defibrotide, that can be considered in CAPS patients refractory to traditional treatment.

publication date

  • January 14, 2017

Research

keywords

  • Antiphospholipid Syndrome

Identity

Scopus Document Identifier

  • 85009949475

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-042915-102529

PubMed ID

  • 28099080

Additional Document Info

volume

  • 68