Upfront lower dose lenalidomide is less toxic and does not compromise efficacy for vulnerable patients with relapsed refractory multiple myeloma: final analysis of the phase II RevLite study. Academic Article uri icon

Overview

abstract

  • The combination of lenalidomide and dexamethasone is an established treatment for patients with multiple myeloma (MM). Increasingly, treatment attenuation is advocated for frail/elderly patients to minimize toxicity even though there have been no prospective studies to demonstrate whether lenalidomide dose attenuation impacts on response and survival outcome. This prospective multicentre phase II study assessed the efficacy and tolerability of lower dose lenalidomide (15 mg) and dexamethasone (20 mg) in 149 eligible patients with relapsed/refractory MM aged over 59 years and/or with renal impairment. The overall response rate was 71% (complete response 15%). Median (range) progression-free survival (PFS) and overall survival (OS) were 8·9 (6·9-11·5) and 30·5 (20·0-36·2) months, respectively. Upon formal statistical comparison of these endpoints to that of a matched cohort of patients from the pivotal phase III MM009/MM010 studies who received standard-dose lenalidomide (25 mg) and high-dose dexamethasone (40 mg) no difference was seen in PFS (P = 0·34) and OS (P = 0·21). Importantly, grade 3-4 toxicities were reduced with low-dose lenalidomide, mainly lower neutropenia (29% vs. 41%), infections (23% vs. 31%) and venous thromboembolism (3% vs. 13%). This study supports a strategy of lenalidomide dose reduction at the outset for at-risk patients, and prospectively confirms that such an approach reduces adverse events while not compromising patient response or survival outcomes.

authors

  • Quach, Hang
  • Fernyhough, Liam Joseph
  • Henderson, Ross
  • Corbett, Gillian
  • Baker, Bart
  • Browett, Peter
  • Blacklock, Hilary
  • Forsyth, Cecily
  • Underhill, Craig
  • Cannell, Paul
  • Trotman, Judith
  • Neylon, Annette
  • Harrison, Simon
  • Link, Emma
  • Swern, Arlene
  • Cowan, Linda
  • Dimopoulos, Meletios A
  • Miles Prince, H

publication date

  • February 15, 2017

Research

keywords

  • Angiogenesis Inhibitors
  • Antineoplastic Combined Chemotherapy Protocols
  • Multiple Myeloma
  • Thalidomide

Identity

Scopus Document Identifier

  • 85013630729

Digital Object Identifier (DOI)

  • 10.1111/bjh.14562

PubMed ID

  • 28197996

Additional Document Info

volume

  • 177

issue

  • 3