Androgen Receptor Signaling in Salivary Gland Cancer. Review uri icon

Overview

abstract

  • Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer.

publication date

  • February 8, 2017

Identity

PubMed Central ID

  • PMC5332940

Scopus Document Identifier

  • 85012283209

Digital Object Identifier (DOI)

  • 10.3390/cancers9020017

PubMed ID

  • 28208703

Additional Document Info

volume

  • 9

issue

  • 2