The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens. Academic Article uri icon

Overview

abstract

  • CONTEXT: Clinical study of breast cancer patients in Chicago, IL, USA. OBJECTIVE: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk. METHODS: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. RESULTS: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI and PBD were positively associated. CONCLUSIONS: Quantitative measurement of SSBs by this procedure indicates the relative number of SSBs and is related to promoter methylation, antioxidant availability and percent breast density.

publication date

  • February 28, 2017

Research

keywords

  • Breast Neoplasms
  • DNA Breaks, Single-Stranded
  • Estrogens

Identity

Scopus Document Identifier

  • 85014445209

Digital Object Identifier (DOI)

  • 10.1080/1354750X.2017.1293736

PubMed ID

  • 28276926

Additional Document Info

volume

  • 22

issue

  • 7