The L-5 protocol: intensive treatment for patients with chronic myeloid leukemia. Academic Article uri icon

Overview

abstract

  • An aggressive treatment program combining splenic irradiation, splenectomy and intensive cytotoxic combination chemotherapy was used in 37 patients with Ph1 chromosome positive chronic myelogenous leukemia. Cytogenetic Ph1 chromosome determination on marrow cells revealed a significant but transient decrease in the Ph1 positive cell population in 12/37 (32%) cases. Survival duration appears longer in patients who show a reduction in the Ph1 positive population. Blastic transformation occurred in 18/37 (49%) cases, not different from our historical control.

publication date

  • July 31, 1978

Research

keywords

  • Leukemia, Myeloid
  • Splenectomy

Identity

Scopus Document Identifier

  • 0018132272

PubMed ID

  • 282899

Additional Document Info

volume

  • 57

issue

  • 3