Automated segmentation of MR imaging to determine normative central nervous system cerebrospinal fluid volumes in healthy volunteers. Academic Article uri icon



  • An accurate non-invasive method to determine total body cerebrospinal fluid volume has a number of potential diagnostic and therapeutic applications. Herein we describe a technique for automated segmentation of total body MRI data to determine cranial and spinal CSF volume in 15 healthy adults. These in vivo estimates of CSF volume exceed the standard reported volume of 150mL in human adults and provide normative data for diagnosis of disease states such as hydrocephalus and therapy including pharmacologic dosimetry. No correlation was observed between patient height or weight and total body CSF volume.

publication date

  • March 2, 2017



  • Central Nervous System
  • Cerebrospinal Fluid
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging


Scopus Document Identifier

  • 85015079243

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2017.02.007

PubMed ID

  • 28314198

Additional Document Info


  • 43