Ethical issues in non-intervention trials for thyroid cancer. Academic Article uri icon

Overview

abstract

  • In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise.

publication date

  • March 16, 2017

Research

keywords

  • Clinical Trials as Topic
  • Ethics, Research
  • Informed Consent
  • Thyroid Neoplasms
  • Watchful Waiting

Identity

Scopus Document Identifier

  • 85016059661

Digital Object Identifier (DOI)

  • 10.1016/j.ejso.2017.03.002

PubMed ID

  • 28343732

Additional Document Info

volume

  • 44

issue

  • 3