Elevated β-hCG associated with aggressive Osteoblastoma. Review uri icon

Overview

abstract

  • We present a unique case of an aggressive scapular osteoblastoma that produced β-hCG as a paraneoplastic manifestation in a 20-year-old woman. Serum β-hCG was found to be elevated during presurgical workup and consequently delayed surgical resection of the increasingly painful tumor because of suspected pregnancy. The paraneoplastic production of β-hCG was later proven by positive immunohistochemical stain of β-hCG in a curettage specimen and normalization of β-hCG levels after surgical resection of the aggressive osteoblastoma. Production of beta-human chorionic gonadotropin (β-hCG) has been reported in several carcinomas and sarcomas but, to our knowledge, it has not been reported in osteoblastoma in the English-language literature.

publication date

  • April 10, 2017

Research

keywords

  • Chorionic Gonadotropin, beta Subunit, Human
  • Osteoblastoma
  • Scapula

Identity

Scopus Document Identifier

  • 85017246106

Digital Object Identifier (DOI)

  • 10.1007/s00256-017-2647-0

PubMed ID

  • 28396962

Additional Document Info

volume

  • 46

issue

  • 9