Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor. Academic Article uri icon

Overview

abstract

  • Lipoprotein lipase (LPL) plays a critical role in the metabolism of plasma lipoproteins. In 3T3-L1 adipocytes, insulin elicits the rapid release of LPL through mechanisms that are independent of energy metabolism and protein synthesis. Some of the metabolic actions of insulin may be mediated by the activation of a specific phospholipase that hydrolyzes a glycosyl phosphatidylinositol (PI) molecule. The insulin-sensitive glycosyl-PI is structurally similar to the glycolipid membrane anchor of a number of proteins. LPL appears to be anchored to the 3T3-L1 cell surface by glycosyl-PI, and its rapid release by insulin may be due to activation of a glycosyl-PI-specific phospholipase C.

publication date

  • September 23, 1988

Research

keywords

  • Insulin
  • Lipoprotein Lipase
  • Phosphatidylinositols

Identity

Scopus Document Identifier

  • 0023784652

PubMed ID

  • 2843987

Additional Document Info

volume

  • 241

issue

  • 4873