Autoantibodies as diagnostic biomarkers for the detection and subtyping of multiple sclerosis. Academic Article uri icon

Overview

abstract

  • The goal of this preliminary proof-of-concept study was to use human protein microarrays to identify blood-based autoantibody biomarkers capable of diagnosing multiple sclerosis (MS). Using sera from 112 subjects, including 51 MS subjects, autoantibody biomarkers effectively differentiated MS subjects from age- and gender-matched normal and breast cancer controls with 95.0% and 100% overall accuracy, but not from subjects with Parkinson's disease. Autoantibody biomarkers were also useful in distinguishing subjects with the relapsing-remitting form of MS from those with the secondary progressive subtype. These results demonstrate that autoantibodies can be used as noninvasive blood-based biomarkers for the detection and subtyping of MS.

publication date

  • May 19, 2017

Research

keywords

  • Autoantibodies
  • Multiple Sclerosis, Chronic Progressive
  • Multiple Sclerosis, Relapsing-Remitting

Identity

Scopus Document Identifier

  • 85019650711

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2017.05.010

PubMed ID

  • 28601288

Additional Document Info

volume

  • 309