ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. Academic Article uri icon

Overview

abstract

  • Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice. Notably, we found that dietary feeding of ω-3 PUFAs significantly increased levels of epoxydocosapentaenoic acids (EDPs, metabolites of ω-3 PUFA produced by cytochrome P450 enzymes) in plasma and tumor tissue of the treated mice. We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues. Together, these results support that formation of EDPs might contribute to the anti-colorectal cancer effects of ω-3 PUFAs.

publication date

  • June 21, 2017

Research

keywords

  • Colorectal Neoplasms
  • Cytochrome P-450 Enzyme System
  • Eicosanoids
  • Fatty Acids, Omega-3
  • Fatty Acids, Unsaturated

Identity

PubMed Central ID

  • PMC6278818

Scopus Document Identifier

  • 85021457282

Digital Object Identifier (DOI)

  • 10.1016/j.jnutbio.2017.06.006

PubMed ID

  • 28672272

Additional Document Info

volume

  • 48