Kidney Toxicities Associated With Novel Cancer Therapies. Review uri icon

Overview

abstract

  • Targeted therapies that act via unique molecular pathways and interfere with cancer cell growth and tumor progression have dramatically changed the cancer treatment paradigm. However, although, ideally, these therapies intend to target only cancer cells, they do often affect nonmalignant tissue. Numerous renal side effects have been reported to date. This article will review clinical presentation, presumed pathophysiology, and treatment of kidney side effects of targeted therapies. Feasibility of the continuation of cancer therapy despite renal toxicity will also be addressed.

publication date

  • July 1, 2017

Research

keywords

  • Acute Kidney Injury
  • Antineoplastic Agents
  • Proteasome Inhibitors
  • Protein Kinase Inhibitors
  • Vascular Endothelial Growth Factors

Identity

Scopus Document Identifier

  • 85026552717

Digital Object Identifier (DOI)

  • 10.1053/j.ackd.2017.05.006

PubMed ID

  • 28778363

Additional Document Info

volume

  • 24

issue

  • 4