Tardive dyskinesia and steady-state serum levels of thiothixene. Academic Article uri icon

Overview

abstract

  • The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.

publication date

  • October 1, 1987

Research

keywords

  • Dyskinesia, Drug-Induced
  • Schizophrenia
  • Thiothixene

Identity

Scopus Document Identifier

  • 0023253292

PubMed ID

  • 2889439

Additional Document Info

volume

  • 44

issue

  • 10