HDL functionality in familial hypercholesterolemia: effects of treatment modalities and pharmacological interventions. Review uri icon

Overview

abstract

  • Recent studies have demonstrated that assessment of high-density lipoprotein (HDL) functionality indices, instead of HDL cholesterol measurement, is a more robust tool for the evaluation of the functional status of HDL and cardiovascular risk. There are qualitative abnormalities of HDL particles in familial hypercholesterolemia (FH) patients that might represent potential therapeutic targets. Despite the potential promise of optimizing HDL functionality for the treatment of FH, there has been no prior comprehensive review focusing on the impact of different lipid-modifying therapies on HDL functionality in FH patients. In the present review, we aim to fulfill this gap and provide a concise summary on the impact of different lipid-modifying therapies on HDL functionality in FH.

publication date

  • October 3, 2017

Research

keywords

  • Cholesterol, HDL
  • Hyperlipoproteinemia Type II
  • Hypolipidemic Agents

Identity

Scopus Document Identifier

  • 85030720228

Digital Object Identifier (DOI)

  • 10.1016/j.drudis.2017.09.014

PubMed ID

  • 28986138

Additional Document Info

volume

  • 23

issue

  • 1