HITs and misses in 100 years of heparin. Academic Article uri icon

Overview

abstract

  • Heparin was discovered 100 years ago, and the heparin-induced thrombocytopenia syndrome was described 40 years ago. That the most powerful anticoagulant of the last century can also produce the most extreme prothrombotic diathesis is but one of the paradoxes that surround heparin-induced thrombocytopenia. Standard treatment is alternative anticoagulation. Advances continue to be made regarding pathophysiology, prevention, and treatment. Currently, an epidemic of overdiagnosis threatens the well-being of patients, so efforts to educate clinicians on when and how to make this diagnosis are pressing.

publication date

  • December 8, 2017

Research

keywords

  • Heparin
  • Thrombocytopenia

Identity

PubMed Central ID

  • PMC6142618

Scopus Document Identifier

  • 85038415731

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2017.1.667

PubMed ID

  • 29222319

Additional Document Info

volume

  • 2017

issue

  • 1