CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi. Academic Article uri icon

Overview

abstract

  • Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1+ mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1+ MNPs express antifungal receptors and activate antifungal responses in a Syk-dependent manner. Genetic ablation of CX3CR1+ MNPs in mice led to changes in gut fungal communities and to severe colitis that was rescued by antifungal treatment. In Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses. These results unravel a role of CX3CR1+ MNPs in mediating interactions between intestinal mycobiota and host immunity at steady state and during inflammatory disease.

publication date

  • January 12, 2018

Research

keywords

  • CX3C Chemokine Receptor 1
  • Candida albicans
  • Gastrointestinal Microbiome
  • Intestines
  • Mycobiome
  • Phagocytes

Identity

PubMed Central ID

  • PMC5805464

Scopus Document Identifier

  • 85040462327

Digital Object Identifier (DOI)

  • 10.1126/science.aao1503

PubMed ID

  • 29326275

Additional Document Info

volume

  • 359

issue

  • 6372