Peripheral neuropathy in patients with multiple sclerosis. Academic Article uri icon

Overview

abstract

  • OBJECTIVES: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. METHODS: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). RESULTS: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). CONCLUSIONS: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.

publication date

  • March 7, 2018

Research

keywords

  • Multiple Sclerosis
  • Peripheral Nervous System Diseases

Identity

PubMed Central ID

  • PMC5841750

Scopus Document Identifier

  • 85043326598

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0193270

PubMed ID

  • 29513761

Additional Document Info

volume

  • 13

issue

  • 3