Cumulative Antiretroviral Exposure Measured in Hair Is Not Associated With Measures of HIV Persistence or Inflammation Among Individuals on Suppressive ART. Conference Paper uri icon

Overview

abstract

  • Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation. These findings suggest that higher systemic ARV exposure may not impact HIV persistence or inflammation.

authors

  • Wilkin, Timothy
  • Gandhi, Monica
  • Gandhi, Rajesh T
  • Stefanescu, Andrei
  • Bosch, Ronald J
  • Cyktor, Joshua C
  • Horng, Howard
  • Louie, Alexander
  • Phung, Nhi
  • Eron, Joseph J
  • Hogg, Evelyn
  • Macatangay, Bernard J C
  • Hensel, Christopher
  • Fletcher, Courtney V
  • Mellors, John W
  • McMahon, Deborah K

publication date

  • June 20, 2018

Research

keywords

  • Anti-Retroviral Agents
  • HIV Infections
  • HIV-1
  • Hair
  • Inflammation
  • Viral Load

Identity

PubMed Central ID

  • PMC6009579

Scopus Document Identifier

  • 85050850101

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiy011

PubMed ID

  • 29529230

Additional Document Info

volume

  • 218

issue

  • 2