Topical therapies for the treatment of anal high-grade squamous intraepithelial lesions. Academic Article uri icon



  • Anal cancer may be prevented by treating anal high-grade squamous intraepithelial lesions (HSIL). Ablative therapies are the most commonly used treatments, but they may not be appropriate for all patients including those with extensive HSIL or bleeding diastheses. Researchers have studied topical therapies for human papillomavirus related lesions including anal HSIL. These therapies include patient-applied 5-fluorouracil, imiquimod and cidofovir, and provider-applied trichloroacetic acid. This review will discuss literature supporting efficacy of these products, which is based mainly on case series with few controlled trials having been conducted. Side effects are common with patient-applied topical therapy often requiring dose reduction and medication to treat pain. However, treatment discontinuations are infrequent. This review will also discuss some approaches to the use of these products in clinical practice.

publication date

  • April 26, 2017


PubMed Central ID

  • PMC5999046

Scopus Document Identifier

  • 85025143319

Digital Object Identifier (DOI)

  • 10.1053/j.scrs.2017.04.006

PubMed ID

  • 29910593

Additional Document Info


  • 28


  • 2