Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. Conference Paper uri icon

Overview

abstract

  • In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which can lead to rapid cardiorespiratory and/or neurological deterioration. Multidisciplinary medical vigilance and the requisite health-care infrastructure are imperative to ensuring optimal patient outcomes, especially as these therapies transition from research protocols to standard care. Herein, authors representing the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Hematopoietic Stem Cell Transplantation (HSCT) Subgroup and the MD Anderson Cancer Center CAR T Cell Therapy-Associated Toxicity (CARTOX) Program have collaborated to provide comprehensive consensus guidelines on the care of children receiving CAR T cell therapy.

authors

publication date

  • January 1, 2019

Research

keywords

  • Acute Lung Injury
  • Hematopoietic Stem Cell Transplantation
  • Immunotherapy, Adoptive
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

Identity

PubMed Central ID

  • PMC7096894

Scopus Document Identifier

  • 85052923365

Digital Object Identifier (DOI)

  • 10.1038/s41571-018-0075-2

PubMed ID

  • 30082906

Additional Document Info

volume

  • 16

issue

  • 1