A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Academic Article uri icon

Overview

abstract

  • Background: In a case-control study, aspirin use was associated with a lower risk of a common prostate cancer molecular subtype, the TMPRSS2:ERG gene fusion. We sought to validate this finding in a prospective cohort.Methods: In the Health Professionals Follow-up Study, 49,395 men reported on aspirin use on biennial questionnaires and were followed for prostate cancer incidence over 23 years. TMPRSS2:ERG status was assessed by IHC for presence of ERG on archival tumor specimens for 912 patients with prostate cancer, of whom 48% were ERG-positive.Results: In multivariable models, we found no association between regular use of aspirin and risk of ERG-positive prostate cancer (HR, 1.02; 95% confidence interval, 0.85-1.23), nor any association with duration or frequency of aspirin use. In restricting to cases with either high Gleason grade or advanced stage disease, there remained no association with aspirin use.Conclusions: Data from this prospective study with repeated assessments of aspirin use do not support the hypothesis that aspirin use is associated with a lower risk of ERG-positive prostate cancer.Impact: Aspirin use is unlikely to lower the risk of this common molecular subtype of prostate cancer. However, there is emerging data supporting the role of other lifestyle and genetic factors underlying the development of the TMPRSS2:ERG fusion. Cancer Epidemiol Biomarkers Prev; 27(10); 1231-3. ©2018 AACR.

publication date

  • August 14, 2018

Research

keywords

  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin
  • Oncogene Proteins, Fusion
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC6170677

Scopus Document Identifier

  • 85054384348

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-18-0510

PubMed ID

  • 30108097

Additional Document Info

volume

  • 27

issue

  • 10