An in-vivo pilot study into the effects of FDG-mNP in cancer in mice. Academic Article uri icon

Overview

abstract

  • PURPOSE: Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving both tumour cells and normal tissue in other organs when FDG-mNPs are administered intravenously or intratumourally in mice. MATERIALS AND METHODS: FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points. RESULTS: In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months. CONCLUSION: Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice.

authors

  • Aras, Omer
  • Pearce, Gillian
  • Watkins, Adam J
  • Nurili, Fuad
  • Medine, Emin Ilker
  • Guldu, Ozge Kozgus
  • Tekin, Volkan
  • Wong, Julian
  • Ma, Xianghong
  • Ting, Richard
  • Unak, Perihan
  • Akin, Oguz

publication date

  • August 20, 2018

Research

keywords

  • Glucose-6-Phosphate
  • Hyperthermia, Induced
  • Magnetite Nanoparticles
  • Neoplasms, Experimental
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC6101388

Scopus Document Identifier

  • 85051801686

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0202482

PubMed ID

  • 30125303

Additional Document Info

volume

  • 13

issue

  • 8