Nephrogenic Diabetes Insipidus. Review uri icon

Overview

abstract

  • Nephrogenic diabetes insipidus (NDI) results from the inability of the late distal tubules and collecting ducts to respond to vasopressin. The lack of ability to concentrate urine results in polyuria and polydipsia. Primary and acquired forms of NDI exist in children. Congenital NDI is a result of mutation in AVPR2 or AQP2 genes. Secondary NDI is associated with electrolyte abnormalities, obstructive uropathy, or certain medications. Management of NDI can be difficult with only symptomatic treatment available, using low-solute diet, diuretics, and prostaglandin inhibitors.

publication date

  • February 1, 2019

Research

keywords

  • Diabetes Insipidus, Nephrogenic

Identity

Scopus Document Identifier

  • 85056733468

Digital Object Identifier (DOI)

  • 10.1016/j.pcl.2018.09.006

PubMed ID

  • 30454745

Additional Document Info

volume

  • 66

issue

  • 1