Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti. Academic Article uri icon

Overview

abstract

  • We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

authors

  • Walsh, Kathleen F
  • Vilbrun, Stalz Charles
  • Souroutzidis, Ariadne
  • Delva, Sobieskye
  • Joissaint, Guy
  • Mathurin, Laurent
  • Ocheretina, Oksana
  • Cremieux, Pierre
  • Pape, Jean W.
  • Koenig, Serena P

publication date

  • August 1, 2019

Research

keywords

  • Antitubercular Agents
  • Isoniazid
  • Tuberculosis, Multidrug-Resistant

Identity

PubMed Central ID

  • PMC7322692

Scopus Document Identifier

  • 85082830747

Digital Object Identifier (DOI)

  • 10.1093/cid/ciz039

PubMed ID

  • 30698688

Additional Document Info

volume

  • 69

issue

  • 4