von Willebrand factor abnormalities and endothelial cell perturbation in a patient with acute thrombotic thrombocytopenic purpura. uri icon

Overview

abstract

  • The plasma of a 63-year-old patient with an initial acute, fatal episode of thrombotic thrombocytopenic purpura (TTP) contained agglutinated platelets and a factor VIII-related von Willebrand factor (vWF) antigen level that was elevated seven-fold above normal. Unusually large vWF multimers derived from endothelial cells were detected in her plasma at the onset of the TTP episode. This is the first patient in whom vWF abnormalities indicative of in vivo endothelial cell damage or perturbation have been found during an acute episode of TTP.

publication date

  • January 1, 1986

Research

keywords

  • Antigens
  • Factor VIII
  • Purpura, Thrombotic Thrombocytopenic
  • von Willebrand Factor

Identity

Scopus Document Identifier

  • 0022897197

Digital Object Identifier (DOI)

  • 10.1097/00000441-198601000-00009

PubMed ID

  • 3079954

Additional Document Info

volume

  • 291

issue

  • 1