About Face: Molecular Aberrations in Head and Neck Mucosal Melanomas. uri icon

Overview

abstract

  • Detailed molecular characterization of a large cohort of mucosal melanomas, most arising from head and neck primaries, suggests that chromosomal translocations and other complex rearrangements have prognostic importance. CDK4 amplification is a frequent event in these rare tumors, and CDK4/6 inhibition may represent a rational clinical trial strategy.See related article by Zhou et al., p. 3548.

publication date

  • April 5, 2019

Research

keywords

  • Head and Neck Neoplasms
  • Melanoma

Identity

PubMed Central ID

  • PMC7463422

Scopus Document Identifier

  • 85067517836

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-19-0658

PubMed ID

  • 30952641

Additional Document Info

volume

  • 25

issue

  • 12