Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics. Academic Article uri icon

Overview

abstract

  • Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until they are activated. The activation strategy is highly modular due to the cyclopropene's ability to be caged by various light- and enzyme-activatable groups. This work describes the next generation of activatable cyclopropenes with a new core scaffold that maintains the activation modularity of the first generation but improves upon the ligation kinetics with s-tetrazines by ≤270-fold.

publication date

  • April 24, 2019

Identity

Scopus Document Identifier

  • 85065546859

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.9b01177

PubMed ID

  • 31017444

Additional Document Info

volume

  • 21

issue

  • 10