A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma. Academic Article uri icon



  • We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures.

publication date

  • April 1, 2020



  • Diffusion Magnetic Resonance Imaging
  • Neuroimaging
  • Retinal Neoplasms
  • Retinoblastoma


Scopus Document Identifier

  • 85069045864

Digital Object Identifier (DOI)

  • 10.1097/MPH.0000000000001523

PubMed ID

  • 31259824

Additional Document Info


  • 42


  • 3