Predictors, burden and impact of cardiac arrhythmias among patients hospitalized with end-stage liver disease. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Cirrhotic cardiomyopathy, hyperammonemia, and hepatorenal syndrome predispose to cardiac arrhythmias in End-stage liver disease (ESLD). OBJECTIVES: Among ESLD hospitalizations, we evaluate the distribution and predictors of arrhythmias and their impact on hospitalization outcomes. METHODS: We selected ESLD records from the Nationwide Inpatient Sample (2007-2014), identified concomitant arrhythmias (tachyarrhythmias and bradyarrhythmias), and their demographic and comorbid characteristics, and estimated the effect of arrhythmia on outcomes (SAS 9.4). RESULTS: Of 57,119 ESLD hospitalizations, 6,615 had arrhythmias with higher odds with increasing age, males, jaundice, hepatorenal syndrome, alcohol use, and cardiopulmonary disorders. The most common arrhythmias were atrial fibrillation, cardiac arrest/asystole, and ventricular tachycardia. After propensity-matching (arrhythmia: no-arrhythmia, 6,609:6,609), arrhythmias were associated with 200% higher mortality, 1.7-days longer stay, $32,880 higher cost, and higher rates of shock, respiratory and kidney failures. CONCLUSIONS: Due to worse outcomes with arrhythmias, there is a need for better screening and follow-up of ESLD patients for dysrhythmias.

authors

  • Adejumo, Adeyinka
  • Adejumo, Kelechi Lauretta
  • Akanbi, Olalekan
  • Adegbala, Oluwole Muyiwa
  • Alayo, Quazim Adegbola
  • Fijabi, Daniel Obadare
  • Ogundipe, Olumuyiwa Akinbolaji
  • Almaddah, Nureddin
  • Pani, Lydie
  • Adeboye, Adedayo

publication date

  • July 16, 2019

Research

keywords

  • Atrial Fibrillation
  • End Stage Liver Disease
  • Heart Arrest
  • Tachycardia, Ventricular

Identity

Scopus Document Identifier

  • 85068830636

Digital Object Identifier (DOI)

  • 10.1016/j.hrtlng.2019.07.002

PubMed ID

  • 31320178

Additional Document Info

volume

  • 49

issue

  • 1