Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis. Article uri icon

Overview

abstract

  • Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the United States. It is important to discover novel cellular targets which are crucial in the pathogenesis of CRC, which could facilitate development of mechanism-based strategies to reduce the risks of CRC. Emerging studies support that the cytochrome P450 (CYP) monooxygenase/soluble epoxide hydrolase (sEH) pathway and their eicosanoid metabolites play critical roles in colonic inflammation and CRC, and could be therapeutically explored for treating or preventing CRC. Here in this review, we discuss recent studies about the roles of the CYP/sEH eicosanoid pathway in the pathogenesis of colonic inflammation and CRC.

publication date

  • January 1, 2019

Research

keywords

  • Carcinogenesis
  • Colorectal Neoplasms
  • Cytochrome P-450 Enzyme System
  • Eicosanoids
  • Signal Transduction

Identity

Scopus Document Identifier

  • 85072716125

Digital Object Identifier (DOI)

  • 10.1007/978-3-030-21735-8_11

PubMed ID

  • 31562626

Additional Document Info

volume

  • 1161