Functional Mitral Regurgitation in Heart Failure. Review uri icon

Overview

abstract

  • Functional mitral regurgitation (FMR) in the setting of left ventricular (LV) dysfunction and heart failure portends a poor prognosis. Guideline-directed medical therapy remains the cornerstone of initial treatment, with emphasis placed on treatment of the underlying LV dysfunction, as FMR is a secondary phenomenon and a disease due to LV remodeling. Surgical correction of FMR is controversial because it typically does not address the underlying mechanism and etiology of the condition. However, new, minimally invasive transcatheter therapies, in particular the MitraClip system, have shown promise in the treatment of FMR in selected patients. This review will summarize the pathophysiology underlying FMR, the prognosis of patients with heart failure and FMR, and the various medical and procedural treatment options currently available and under investigation.

publication date

  • November 1, 2019

Research

keywords

  • Heart Failure
  • Mitral Valve Insufficiency

Identity

Scopus Document Identifier

  • 85072934094

Digital Object Identifier (DOI)

  • 10.1097/CRD.0000000000000269

PubMed ID

  • 31584475

Additional Document Info

volume

  • 27

issue

  • 6