Assisted reproductive technologies for women with rheumatic AID. Review uri icon

Overview

abstract

  • Assisted reproductive technology (ART) procedures are safe for women with rheumatic autoimmune diseases (rAID) when illness is inactive. Medications incompatible with pregnancy should be replaced with alternative pregnancy-compatible medications months before planned ART procedures to allow time to verify the substitute medication's efficacy and tolerability. Medications compatible with pregnancy should be continued, as should anticoagulation (warfarin changed to low-molecular-weight heparin) before pregnancy begins. Protocols that provide details for specific medications are available. All patients with rAID should be screened for diagnosis-relevant organ system damage, and those intending to carry their own pregnancies must be tested for aPL and anti-Ro/La autoantibodies. Patients with organ damage and/or positive tests for aPL and anti-Ro/La should be counseled about fetal and maternal risks, including implications to the child and family of maternal disability or death. Sperm donors with rAID may need to discontinue medications. REI and physicians treating patients with rAID (usually rheumatologists) must work together to plan and accomplish ART.

publication date

  • October 23, 2019

Research

keywords

  • Reproductive Techniques, Assisted
  • Rheumatic Diseases

Identity

Scopus Document Identifier

  • 85083420803

Digital Object Identifier (DOI)

  • 10.1016/j.bpobgyn.2019.10.002

PubMed ID

  • 31791669

Additional Document Info

volume

  • 64