Antibiotic Prophylaxis Trials in Obstetrics: A Call for Pediatric Collaboration. uri icon

Overview

abstract

  • Surgical site infections are common complications of cesarean delivery. Many recent studies, including meta-analyses, have assessed the efficacy of antibiotic prophylaxis. Those articles have demonstrated that preincision antibiotic prophylaxis reduces the incidence of surgical site infections postcesarean, and that the use of adjunctive azithromycin further reduces infection after nonelective cesarean deliveries. However, long-term effects of fetal exposure to antibiotic prophylaxis-including asthma, obesity, and alterations in microbiota-have also been demonstrated. We suggest that while studies of optimal antibiotic regimens proceed, considerations of the potential risks to the neonate should be factored into discussions of benefits and burdens.

publication date

  • April 15, 2020

Identity

PubMed Central ID

  • PMC7159977

Scopus Document Identifier

  • 85083902817

Digital Object Identifier (DOI)

  • 10.1055/s-0040-1709513

PubMed ID

  • 32309017

Additional Document Info

volume

  • 10

issue

  • 2