Targeting Vascular Calcification in Chronic Kidney Disease. Review uri icon

Overview

abstract

  • Cardiovascular (CV) disease remains an important cause of morbidity and mortality for patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with CKD is well recognized, kidney-specific mechanisms are believed to drive the disproportionate burden of CV disease. One perturbation that is frequently observed at high rates in patients with CKD is vascular calcification, which may be a central mediator for an array of CV sequelae. This review summarizes the pathophysiological bases of intimal and medial vascular calcification in CKD, current strategies for diagnosis and management, and posits vascular calcification as a risk marker and therapeutic target.

publication date

  • April 27, 2020

Identity

PubMed Central ID

  • PMC7188874

Scopus Document Identifier

  • 85083380468

Digital Object Identifier (DOI)

  • 10.1016/j.jacbts.2020.02.002

PubMed ID

  • 32368697

Additional Document Info

volume

  • 5

issue

  • 4