Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation. Review uri icon

Overview

abstract

  • BACKGROUND: Women with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited. CASE: This is the case of a woman with a BRCA1 mutation who underwent prophylactic mastectomy and bilateral salpingectomy with ovarian retention before the age of 40 years. She did not undergo oophorectomy and subsequently developed stage IV high-grade serous ovarian cancer 4 years after her initial surgery. CONCLUSION: More research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophorectomy, and the risks and benefits compared with up-front risk-reducing salpingo-oophorectomy.

publication date

  • June 1, 2020

Research

keywords

  • Carcinoma, Ovarian Epithelial
  • Genes, BRCA1
  • Ovarian Neoplasms

Identity

PubMed Central ID

  • PMC7263355

Scopus Document Identifier

  • 85085539151

Digital Object Identifier (DOI)

  • 10.1097/AOG.0000000000003864

PubMed ID

  • 32459417

Additional Document Info

volume

  • 135

issue

  • 6