Ca2+ signaling and lipid transfer 'pas a deux' at ER-PM contact sites orchestrate cell migration. Review uri icon

Overview

abstract

  • Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca2+ signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca2+ entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.

publication date

  • June 1, 2020

Research

keywords

  • Calcium Signaling
  • Cell Membrane
  • Cell Movement
  • Endoplasmic Reticulum
  • Lipids

Identity

Scopus Document Identifier

  • 85085655326

Digital Object Identifier (DOI)

  • 10.1016/j.ceca.2020.102226

PubMed ID

  • 32505782

Additional Document Info

volume

  • 89