Hepatitis c virus and chronic kidney disease. Review uri icon

Overview

abstract

  • INTRODUCTION: Hepatitis C virus (HCV) infection is associated with an increased incidence and progression of chronic kidney disease (CKD), as well as higher mortality in CKD and renal transplant patients. Direct acting antiviral agents (DAAs) have revolutionized the treatment of HCV, with viral eradication attained in 90-100% of treated patients. DAAs have an excellent safety and tolerability profile in CKD and renal transplant patients. AREAS COVERED: In this review, we discuss the association of HCV with incidence and progression of CKD as well as its effect on outcomes and mortality. We also discuss the available treatment options in patients with CKD and renal transplant and in HCV-associated glomerular disease. EXPERT OPINION: The availability of newly available direct acting anti-viral agents has revolutionized the treatment of HCV in persons with advanced CKD and undergoing dialysis. With these regimens, viral eradication can be attained in 90-100% of the treated patients. The safety, tolerability, and efficacy of these drugs in renal transplant patients have also made it possible to use HCV-infected grafts and successful virus eradication at a later stage.

publication date

  • July 2, 2020

Research

keywords

  • Antiviral Agents
  • Hepatitis C, Chronic
  • Renal Insufficiency, Chronic

Identity

Scopus Document Identifier

  • 85087776898

Digital Object Identifier (DOI)

  • 10.1080/17474124.2020.1776111

PubMed ID

  • 32613874

Additional Document Info

volume

  • 14

issue

  • 7