Poor graft function after T cell-depleted allogeneic hematopoietic stem cell transplant. Academic Article uri icon

Overview

abstract

  • PGF implies persistent cytopenia in the presence of predominant donor chimerism. We examined contributors to PGF in 104 HCT recipients who survived ≥100 days without relapse or major complications. Surrogate parameters for PGF were: Hg <10 g/dl, RBC transfusion dependence, platelet count <20 × 109/L or ANC < 0.5 × 109/L. All patients received T cell depletion with alemtuzumab or ATG. The 2-year OS and PFS probabilities were 66%, 95%CI (56 - 75%) and 51%, 95%CI (41-60%) respectively. Fifty-four patients (52%) met one or more PGF criteria. There was significant association between major ABO incompatibility and platelet <20 × 109/L (OR = 4.7, 95%CI 1.05-21.26, p = .043), acute GVHD and Hg <10 g/dl (OR 3.7, 95%CI 1.4-9.6, p = .005) and CMV viremia and ANC < 0.5 × 109/L (OR 3.0, 95% CI 1.0, 8.7, p = .043). NRM was significantly higher in the PGF group compared to patients with adequate graft function (45.5% vs 16.7%, p = .014).

publication date

  • July 14, 2020

Research

keywords

  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation

Identity

Scopus Document Identifier

  • 85088152512

Digital Object Identifier (DOI)

  • 10.1080/10428194.2020.1789622

PubMed ID

  • 32662694

Additional Document Info

volume

  • 61

issue

  • 12