Ocular measurements in fetal alcohol spectrum disorders. Academic Article uri icon

Overview

abstract

  • Fetal alcohol spectrum disorders (FASD) describe a range of physical, behavioral, and neurologic deficits in individuals exposed to alcohol prenatally. Reduced palpebral fissure length is one of the cardinal facial features of FASD. However, other ocular measurements have not been studied extensively in FASD. Using the Fetal Alcohol Syndrome Epidemiologic Research (FASER) database, we investigated how inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance (OCD) centiles differed between FASD and non-FASD individuals. We compared ocular measurement centiles in children with FASD to non-FASD individuals and observed reductions in all three centiles for ICD, IPD, and OCD. However, when our non-FASD children who had various forms of growth deficiency (microcephaly, short-stature, or underweight) were compared to controls, we did not observe a similar reduction in ocular measurements. This suggests that reductions in ocular measurements are a direct effect of alcohol on ocular development independent of its effect on growth parameters, which is consistent with animal models showing a negative effect of alcohol on developing neural crest cells. Interpupillary distance centile appeared to be the most significantly reduced ocular measure we evaluated, suggesting it may be a useful measure to be considered in the diagnosis of FASD.

publication date

  • July 17, 2020

Research

keywords

  • Alcohol Drinking
  • Fetal Alcohol Spectrum Disorders
  • Microcephaly
  • Neural Crest

Identity

Scopus Document Identifier

  • 85087945131

Digital Object Identifier (DOI)

  • 10.1002/ajmg.a.61759

PubMed ID

  • 32677343

Additional Document Info

volume

  • 182

issue

  • 10