A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia. Academic Article uri icon

Overview

abstract

  • The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden.This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017.

publication date

  • November 6, 2020

Research

keywords

  • Dideoxynucleosides
  • Positron Emission Tomography Computed Tomography
  • Primary Myelofibrosis
  • Thrombocythemia, Essential

Identity

PubMed Central ID

  • PMC7647608

Scopus Document Identifier

  • 85095802688

Digital Object Identifier (DOI)

  • 10.1097/MD.0000000000023088

PubMed ID

  • 33157979

Additional Document Info

volume

  • 99

issue

  • 45