Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review. Review uri icon

Overview

abstract

  • Over 1.5 million deaths worldwide are caused by neurocardiogenic syndromes. Furthermore, the consequences of deleterious brain-heart interactions are not limited to fatal complications. Cardiac arrhythmias, heart failure, and nonfatal coronary syndromes are also common. The brain-heart axis is implicated in post-stroke cardiovascular complications known as the stroke-heart syndrome, sudden cardiac death, and Takotsubo syndrome, among other neurocardiogenic syndromes. Multiple pathophysiological mechanisms with the potential to be targeted with novel therapies have been identified in the last decade. In the present state-of-the-art review, we describe recent advances in the understanding of anatomical and functional aspects of the brain-heart axis, cardiovascular complications after stroke, and a comprehensive pathophysiological model of stroke-induced cardiac injury.

publication date

  • December 8, 2020

Research

keywords

  • Autonomic Nervous System
  • Heart Diseases
  • Stroke

Identity

Scopus Document Identifier

  • 85096464623

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2020.10.009

PubMed ID

  • 33272372

Additional Document Info

volume

  • 76

issue

  • 23