The receptor for advanced glycation end product (RAGE) pathway in COVID-19. Academic Article uri icon

Overview

abstract

  • INTRODUCTION: Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor. The receptor for advanced glycation end-product (RAGE) pathway is considered to play important roles in the physiological aging and pathogenesis of lung diseases. This study aimed to investigate the possible relationship between COVID-19 and RAGE pathway. MATERIALS AND METHODS: This study included 23 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed tomography. Serum soluble-RAGE (sRAGE) levels were determined using enzyme-linked immunosorbent assay. RESULTS: The sRAGE levels were significantly higher in the asymptomatic group than in the control group. Age, fibrinogen, C-reactive protein, and ferritin levels were higher and the sRAGE level was lower in the patients with lung involvement than in the asymptomatic patients. CONCLUSIONS: In this study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19.

publication date

  • January 13, 2021

Research

keywords

  • Antigens, Neoplasm
  • COVID-19
  • Mitogen-Activated Protein Kinases
  • Signal Transduction

Identity

PubMed Central ID

  • PMC7814566

Scopus Document Identifier

  • 85099443792

Digital Object Identifier (DOI)

  • 10.1080/1354750X.2020.1861099

PubMed ID

  • 33284049

Additional Document Info

volume

  • 26

issue

  • 2