Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases. Review uri icon

Overview

abstract

  • The intestinal microbiota comprises diverse fungal and viral components, in addition to bacteria. These microbes interact with the immune system and affect human physiology. Advances in metagenomics have associated inflammatory and autoimmune diseases with alterations in fungal and viral species in the gut. Studies of animal models have found that commensal fungi and viruses can activate host-protective immune pathways related to epithelial barrier integrity, but can also induce reactions that contribute to events associated with inflammatory bowel disease. Changes in our environment associated with modernization and the COVID-19 pandemic have exposed humans to new fungi and viruses, with unknown consequences. We review the lessons learned from studies of animal viruses and fungi commonly detected in the human gut and how these might affect health and intestinal disease.

publication date

  • December 19, 2020

Research

keywords

  • Gastrointestinal Microbiome
  • Immunity
  • Inflammatory Bowel Diseases
  • Mycobiome
  • Virome

Identity

PubMed Central ID

  • PMC7956156

Scopus Document Identifier

  • 85100810903

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2020.06.100

PubMed ID

  • 33347881

Additional Document Info

volume

  • 160

issue

  • 4