Ringed sideroblasts in primary myelodysplasia. Leukemic propensity and prognostic factors. Academic Article uri icon

Overview

abstract

  • Among 123 patients with ringed sideroblasts on bone marrow aspirates, 85 had acquired ringed sideroblasts with primary myelodysplasia. The patients were placed in categories modified from the French-American-British classification based on percentages of ringed sideroblasts and myeloblasts in the initial bone marrow. Overall, 48% (41/85) of patients with myelodysplasia developed acute leukemia. Primary acquired sideroblastic anemia was the most favorable category with longer survival and 13.8% (4/29) leukemic conversions. Variables correlating with leukemic transformation included male sex, thrombocytopenia, neutropenia, and pseudo-Pelger-Hu√ęt neutrophils. Only two variables had independent predictive value by multivariate regression analysis: a high percentage of myeloblasts and a low percentage of ringed sideroblasts. Numerous ringed sideroblasts strongly predicts a more favorable course in myelodysplastic patients.

publication date

  • March 1, 1988

Research

keywords

  • Bone Marrow
  • Cell Transformation, Neoplastic
  • Leukemia
  • Myelodysplastic Syndromes

Identity

Scopus Document Identifier

  • 0023864896

PubMed ID

  • 3341866

Additional Document Info

volume

  • 148

issue

  • 3