Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor. Academic Article uri icon

Overview

abstract

  • Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5 to 10) rescues a significant number of motoneurons from degeneration. The survival activity of partially purified extract was dose-dependent and developmentally regulated. The survival of sensory, sympathetic, parasympathetic, and a population of cholinergic sympathetic preganglionic neurons was unaffected by treatment with hindlimb extract. The massive motoneuron death that occurs after early target (hindlimb) removal was partially ameliorated by daily treatment with the hindlimb extract. These results indicate that a target-derived neurotrophic factor is involved in the regulation of motoneuron survival in vivo.

publication date

  • May 13, 1988

Research

keywords

  • Growth Substances
  • Motor Neurons

Identity

Scopus Document Identifier

  • 0023881779

PubMed ID

  • 3363373

Additional Document Info

volume

  • 240

issue

  • 4854