Epigenetic Dysregulation of Myeloproliferative Neoplasms. Review uri icon

Overview

abstract

  • This article reviews the genetic data on epigenetic modifying mutations in myeloproliferative neoplasms and their clinical implications, preclinical studies exploring our current understanding of how mutations in epigenetic modifying proteins cooperate with myeloproliferative neoplasms drivers to promote disease progression, and recent advances in novel therapeutics supporting the role of targeting epigenetic pathways to treat fibrotic progression.

publication date

  • February 5, 2021

Research

keywords

  • Epigenesis, Genetic
  • Myeloproliferative Disorders
  • Neoplasms

Identity

PubMed Central ID

  • PMC7927771

Scopus Document Identifier

  • 85100436403

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2021.01.001

PubMed ID

  • 33641866

Additional Document Info

volume

  • 35

issue

  • 2