Sex-based differences in severity and mortality in COVID-19. Review uri icon

Overview

abstract

  • The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.

publication date

  • March 1, 2021

Research

keywords

  • Adaptive Immunity
  • COVID-19
  • Immunity, Innate
  • SARS-CoV-2
  • Sex Characteristics

Identity

PubMed Central ID

  • PMC8014761

Scopus Document Identifier

  • 85101814155

Digital Object Identifier (DOI)

  • 10.1002/rmv.2223

PubMed ID

  • 33646622

Additional Document Info

volume

  • 31

issue

  • 6