Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy. Academic Article uri icon

Overview

abstract

  • Aging is associated with a number of histological changes in the choroid, Bruch's membrane, RPE, and neuroretina. Outside of the normal physiologic aging spectrum of changes, abnormal deposits such as basal laminar deposits, basal linear deposits, and soft drusen are known to be associated with AMD. Progression of AMD to advanced stages involving geographic atrophy, choroidal neovascularization, and/or disciform scars can result in debilitating vision loss. Knowledge of the angiogenic pathway and its components that stimulate neovascularization has led to the development of a new paradigm of intravitreal anti-VEGF pharmacotherapy in the management of neovascular AMD. Currently however, there are no available treatments for the modification of disease progression in non-neovascular AMD, or for the treatment of geographic atrophy. Further understanding of the histopathology of AMD and the molecular mechanisms that contribute to pathogenesis of the disease may reveal additional therapeutic targets.

publication date

  • January 1, 2021

Research

keywords

  • Angiogenesis Inhibitors
  • Wet Macular Degeneration

Identity

Scopus Document Identifier

  • 85104314530

Digital Object Identifier (DOI)

  • 10.1007/978-3-030-66014-7_3

PubMed ID

  • 33847998

Additional Document Info

volume

  • 1256