Flavonoids in the Treatment of Neuropathic Pain. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. RECENT FINDINGS: Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.

publication date

  • May 7, 2021

Research

keywords

  • Flavonoids
  • Neuralgia

Identity

Scopus Document Identifier

  • 85105464156

Digital Object Identifier (DOI)

  • 10.1007/s11916-021-00959-y

PubMed ID

  • 33961144

Additional Document Info

volume

  • 25

issue

  • 7