Promoting spliceosome assembly for therapeutic intent. Academic Article uri icon

Overview

abstract

  • RNA splicing, the process by which precursor mRNA (pre-mRNA) is processed to mature mRNA, is catalyzed by the spliceosome. Recently, Chatrikhi et al. identified pharmacologic means to perturb splicing by enhancing the spliceosome's binding to pre-mRNA. This represents a novel chemical target and mechanism for therapeutic modulation of splicing.

publication date

  • September 30, 2021

Research

keywords

  • RNA Precursors
  • Spliceosomes

Identity

Scopus Document Identifier

  • 85116162899

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2021.09.006

PubMed ID

  • 34602305

Additional Document Info

volume

  • 42

issue

  • 12